Cytoplasmic domains of the common beta-chain of the GM-CSF/IL-3/IL-5 receptors that are required for inducing differentiation or clonal suppression in myeloid leukaemic cell lines.

doi:10.1093/emboj/16.3.451

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Article

Cytoplasmic domains of the common beta-chain of the GM-CSF/IL-3/IL-5 receptors that are required for inducing differentiation or clonal suppression in myeloid leukaemic cell lines.

The EMBO journal - 3 Feb 1997

Smith A, Metcalf D, Nicola N A

Abstract excerpt

Granulocyte-macrophage colony stimulating factor (GM-CSF) is a cytokine that controls the production and function of myeloid cells by interaction with a cell surface receptor composed of a specific ligand-binding alpha-chain (hGMRalpha) and a shared signal-transducing beta-chain (beta c). Co-expr...

Topics

Animals
Blotting, Western
Cell Differentiation
Cell Division
Clone Cells
Flow Cytometry
Gene Expression Regulation, Neoplastic
Granulocyte-Macrophage Colony-Stimulating Factor
Hematopoiesis
Humans
Interleukins
Leukemia, Myeloid
Macrophages
Mice
Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 9034328
DOI: 10.1093/emboj/16.3.451
PMCID: PMC1169649

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9034328-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Phosphorylation

Receptors, Cell Surface

Receptors, Granulocyte-Macrophage Colony-Stimulating Factor