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Article

Characterization of the leukemogenic potential of distal cytoplasmic CSF3R truncation and missense mutations.

Leukemia - 1 Dec 2017

Zhang H, Reister Schultz A, Luty S, Rofelty A, Su Y, Means S, Bottomly D, Wilmot B, McWeeney S K, Tyner J W

Abstract excerpt

An increasing number of variants of unknown significance are being identified in leukemia patients with the application of deep sequencing and these include CSF3R cytoplasmic mutations. Previous studies have demonstrated oncogenic potential of certain CSF3R truncation mutations prior to internalization motifs. However, the oncogenic potential of truncating the more distal region of CSF3R cytoplasmic domain as...

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Identifiers

PMID: 28439110
DOI: 10.1038/leu.2017.126
PMCID: PMC5682244

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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