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Article

Genetic regulation of leishmanial and mycobacterial infections: the Lsh/Ity/Bcg gene story continues.

Immunology letters - 1 Dec 1994

Blackwell J M, Barton C H, White J K, Roach T I, Shaw M A, Whitehead S H, Mock B A, Searle S, Williams H, Baker A M

Abstract excerpt

A common basis to genetic regulation of leishmanial and mycobacterial infections is provided by the action of the murine Lsh/Ity/Bcg gene in controlling the priming/activation of macrophages for antimicrobial activity. This relies on the TNF-alpha-dependent sustained expression of the inducible nitric oxide synthase (iNOS) gene responsible for the generation of large amounts of toxic nitric oxide (NO). The...

Topics

Amino Acid Sequence
Animals
Carrier Proteins
Cation Transport Proteins
Genetic Predisposition to Disease
Humans
Iron-Binding Proteins
Leishmaniasis
Leprosy
Macrophage Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Proteins

Mice

Molecular Sequence Data

Mycobacterium Infections

Tuberculosis

Source

Identifiers

PMID: 7737696
DOI: 10.1016/0165-2478(94)00161-8

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7737696-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Genetic regulation of leishmanial and mycobacterial infections: the Lsh/Ity/Bcg gene story continues.PMID 7737696Read ↗

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