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Article

Genetic regulation of leishmanial and mycobacterial infections: the Lsh/Ity/Bcg gene story continues.

Immunology letters - 1 Dec 1994

Blackwell J M, Barton C H, White J K, Roach T I, Shaw M A, Whitehead S H, Mock B A, Searle S, Williams H, Baker A M

Abstract excerpt

A common basis to genetic regulation of leishmanial and mycobacterial infections is provided by the action of the murine Lsh/Ity/Bcg gene in controlling the priming/activation of macrophages for antimicrobial activity. This relies on the TNF-alpha-dependent sustained expression of the inducible nitric oxide synthase (iNOS) gene responsible for the generation of large amounts of toxic nitric oxide (NO). The...

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PMID: 7737696
DOI: 10.1016/0165-2478(94)00161-8

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TNF

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