The Bcg/Ity/Lsh locus: genetic transfer of resistance to infections in C57BL/6J mice transgenic for the Nramp1 Gly169 allele.

doi:10.1128/iai.64.8.2923-2929.1996

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

The Bcg/Ity/Lsh locus: genetic transfer of resistance to infections in C57BL/6J mice transgenic for the Nramp1 Gly169 allele.

Infection and immunity - 1 Aug 1996

Govoni G, Vidal S, Gauthier S, Skamene E, Malo D, Gros P

Abstract excerpt

The murine Bcg/Ity/Lsh locus determines the susceptibilities of inbred strains to infection with unrelated intracellular parasites, such as Mycobacterium bovis, Salmonella typhimurium, and Leishmania donovani. A candidate for Bcg/Ity/Lsh, designated Nramp1, has been recently identified and shown...

Topics

Alleles
Animals
Carrier Proteins
Cation Transport Proteins
Chromosome Mapping
Crosses, Genetic
Female
Genotype
Glycine
Immunity, Innate
Male
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred C57BL

Mice, Transgenic

Mutation

Mycobacterium bovis

Tuberculosis

Source

Open in PubMed Open full text

Identifiers

PMID: 8757814
DOI: 10.1128/iai.64.8.2923-2929.1996
PMCID: PMC174168

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8757814-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Bcg/Ity/Lsh locus: genetic transfer of resistance to infections in C57BL/6J mice transgenic for the Nramp1 Gly169 allele.PMID 8757814Read ↗

Natural resistance to intracellular infections: Nramp1 encodes a membrane phosphoglycoprotein absent in macrophages from susceptible (Nramp1 D169) mouse strains.Semantic proximity Read ↗

The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.Semantic proximity Read ↗

Salmonella enterica Causes More Severe Inflammatory Disease in C57/BL6 Nramp1 G169 Mice Than Sv129S6 MiceSemantic proximity Read ↗

Haplotype mapping and sequence analysis of the mouse Nramp gene predict susceptibility to infection with intracellular parasites.Semantic proximity Read ↗

Genetic regulation of macrophage activation: understanding the function of Nramp1 (=Ity/Lsh/Bcg).Semantic proximity Read ↗

Genetic regulation of leishmanial and mycobacterial infections: the Lsh/Ity/Bcg gene story continues.Semantic proximity Read ↗

Temporal and anatomical host resistance to chronic Salmonella infection is quantitatively dictated by Nramp1 and influenced by host genetic background.Semantic proximity Read ↗

Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story.Semantic proximity Read ↗

Natural resistance to intracellular pathogens: modulation of macrophage signal transduction related to the expression of the Bcg locus.Semantic proximity Read ↗

Resistance to salmonellosis in the chicken is linked to NRAMP1 and TNC.Semantic proximity Read ↗

Complex genetic control of susceptibility to Mycobacterium bovis (Bacille Calmette-Guérin) infection in wild-derived Mus spretus mice.Semantic proximity Read ↗

Resistance of Mice of the 129 Background to Yersinia pestis Maps to Multiple Loci on Chromosome 1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.