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Article

The Bcg/Ity/Lsh locus: genetic transfer of resistance to infections in C57BL/6J mice transgenic for the Nramp1 Gly169 allele.

Infection and immunity - 1 Aug 1996

Govoni G, Vidal S, Gauthier S, Skamene E, Malo D, Gros P

Abstract excerpt

The murine Bcg/Ity/Lsh locus determines the susceptibilities of inbred strains to infection with unrelated intracellular parasites, such as Mycobacterium bovis, Salmonella typhimurium, and Leishmania donovani. A candidate for Bcg/Ity/Lsh, designated Nramp1, has been recently identified and shown to encode a novel integral membrane protein that is expressed exclusively in professional phagocytes but whose function...

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Identifiers

PMID: 8757814
DOI: 10.1128/iai.64.8.2923-2929.1996
PMCID: PMC174168

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The Bcg/Ity/Lsh locus: genetic transfer of resistance to infections in C57BL/6J mice transgenic for the Nramp1 Gly169 allele.PMID 8757814Read ↗

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The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.Semantic proximity Read ↗

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Haplotype mapping and sequence analysis of the mouse Nramp gene predict susceptibility to infection with intracellular parasites.Semantic proximity Read ↗

Genetic regulation of macrophage activation: understanding the function of Nramp1 (=Ity/Lsh/Bcg).Semantic proximity Read ↗

Genetic regulation of leishmanial and mycobacterial infections: the Lsh/Ity/Bcg gene story continues.Semantic proximity Read ↗

Temporal and anatomical host resistance to chronic Salmonella infection is quantitatively dictated by Nramp1 and influenced by host genetic background.Semantic proximity Read ↗

Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story.Semantic proximity Read ↗

Natural resistance to intracellular pathogens: modulation of macrophage signal transduction related to the expression of the Bcg locus.Semantic proximity Read ↗

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Resistance of Mice of the 129 Background to Yersinia pestis Maps to Multiple Loci on Chromosome 1.Semantic proximity Read ↗

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