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Article

Natural resistance to intracellular pathogens: modulation of macrophage signal transduction related to the expression of the Bcg locus.

Proteomics - 1 Apr 2001

Kovárová H, Necasová R, Porkertová S, Radzioch D, Macela A

Abstract excerpt

In mice, the Bcg/Nramp1 gene of the chromosome 1 has been implicated in natural resistance or susceptibility to infection with several intramacrophage microorganisms. Functional studies of Bcg/Nramp1 congenic macrophages have shown that this gene has many pleiotropic effects on macrophage activation and function. Although a specific role of Bcg/Nramp1 in the control of pleiotropic effects has not been defined...

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Identifiers

PMID: 11681211
DOI: 10.1002/1615-9861(200104)1:4<587::AID-PROT587>3.0.CO;2-T

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