Article
The Bcg host-resistance gene.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Sept 2000
Buu N, Sánchez F, Schurr E
Abstract excerpt
In the mouse, resistance and susceptibility to intracellular growth of mycobacteria in macrophages is controlled by the Bcg (Nramp1) gene, which has been cloned and shown to encode a macrophage phagosomal membrane protein with a putative transporter function. In the homologous human NRAMP1 gene, a total of 11 polymorphisms have been identified, which are being used to test for the linkage of NRAMP1 alleles with...
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