Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Infection genomics: Nramp1 as a major determinant of natural resistance to intracellular infections.

Annual review of medicine - 1 Jan 1998

Skamene E, Schurr E, Gros P

Abstract excerpt

The scope of the tuberculosis (TB) epidemic in the world today is enormous, with about 30 million active cases. Current research into preventing the spread of TB is focused on development of new drugs to inactivate Mycobacterium tuberculosis, the causative agent of TB, as well as on identifying the critical steps of host defense to infection with Mycobacteria, which might also yield therapeutic targets. Our...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Carrier Proteins
Share to Disease Outbreaks

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Disease Susceptibility

Share to Genetic Linkage

Share to Genetic Predisposition to Disease

Share to Genome, Human

Share to Immunity, Innate

Source

Identifiers

PMID: 9509263
DOI: 10.1146/annurev.med.49.1.275

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Infection genomics: Nramp1 as a major determinant of natural resistance to intracellular infections.PMID 9509263Read ↗

The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.Semantic proximity Read ↗

Genetic control of resistance to experimental infection with virulent Mycobacterium tuberculosis.Semantic proximity Read ↗

The Nramp1 protein and its role in resistance to infection and macrophage function.Semantic proximity Read ↗

Haplotype mapping and sequence analysis of the mouse Nramp gene predict susceptibility to infection with intracellular parasites.Semantic proximity Read ↗

Structure and function of the natural-resistance-associated macrophage protein (Nramp1), a candidate protein for infectious and autoimmune disease susceptibility.Semantic proximity Read ↗

The Bcg host-resistance gene.Semantic proximity Read ↗

Genetics of host resistance and susceptibility to intramacrophage pathogens: a study of multicase families of tuberculosis, leprosy and leishmaniasis in north-eastern Brazil.Semantic proximity Read ↗

A Nonribosomal Peptide Synthase Gene Driving Virulence in Mycobacterium tuberculosisSemantic proximity Read ↗

Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression.Semantic proximity Read ↗

Susceptibility to mycobacterial infections: the importance of host genetics.Semantic proximity Read ↗

Identification of polymorphisms and sequence variants in the human homologue of the mouse natural resistance-associated macrophage protein gene.Semantic proximity Read ↗

Human Genomics of Mycobacterium tuberculosis Infection and DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.