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Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression.

1 Nov 1994

Abstract excerpt

Natural resistance to infection with unrelated intracellular parasites such as Mycobacteria, Salmonella, and Leishmania is controlled in the mouse by a single gene on chromosome 1, designated Bcg, Ity, or Lsh. A candidate gene for Bcg, designated natural resistance-associated macrophage protein (Nramp), has been isolated and shown to encode a novel macrophage-specific membrane protein, which is altered in...

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PMID: 7964458
DOI: 10.1084/jem.180.5.1741

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Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression.PMID 7964458Read ↗

Identification of polymorphisms and sequence variants in the human homologue of the mouse natural resistance-associated macrophage protein gene.Semantic proximity Read ↗

The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.Semantic proximity Read ↗

Structure and function of the natural-resistance-associated macrophage protein (Nramp1), a candidate protein for infectious and autoimmune disease susceptibility.Semantic proximity Read ↗

The Nramp1 protein and its role in resistance to infection and macrophage function.Semantic proximity Read ↗

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Infection genomics: Nramp1 as a major determinant of natural resistance to intracellular infections.Semantic proximity Read ↗

The Bcg host-resistance gene.Semantic proximity Read ↗

Rapid communication: cloning of a pig full-length natural resistance associated macrophage protein (NRAMP1) cDNA.Semantic proximity Read ↗

Genomic organization and sequence of the human NRAMP gene: identification and mapping of a promoter region polymorphism.Semantic proximity Read ↗

Genetic regulation of macrophage activation: understanding the function of Nramp1 (=Ity/Lsh/Bcg).Semantic proximity Read ↗

Haplotype mapping and sequence analysis of the mouse Nramp gene predict susceptibility to infection with intracellular parasites.Semantic proximity Read ↗

Genetic regulation of leishmanial and mycobacterial infections: the Lsh/Ity/Bcg gene story continues.Semantic proximity Read ↗

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