Article
The dopamine D3 receptor (DRD3) Ser9Gly polymorphism and schizophrenia: a haplotype relative risk study and association with clozapine response.
Molecular psychiatry - 1 Jan 1998
Malhotra A K, Goldman D, Buchanan R W, Rooney W, Clifton A, Kosmidis M H, Breier A, Pickar D
Abstract excerpt
Several lines of evidence suggest that the dopamine D3 receptor is involved in the pathophysiology of schizophrenia. The D3 receptor gene (DRD3) contains a polymorphism resulting in a serine-glycine substitution in the N-terminus of the receptor. Shaikh and colleagues have reported a significant...
Topics
- Alleles
- Antipsychotic Agents
- Child
- Clozapine
- Female
- Genetic Carrier Screening
- Genotype
- Glycine
- Haplotypes
- Humans
- Male
- Nuclear Family
- Point Mutation
- Polymerase Chain Reaction
- Receptors, Dopamine D2
- Receptors, Dopamine D3
- Risk
- Schizophrenia