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Article

The dopamine D3 receptor (DRD3) Ser9Gly polymorphism and schizophrenia: a haplotype relative risk study and association with clozapine response.

Molecular psychiatry - 1 Jan 1998

Malhotra A K, Goldman D, Buchanan R W, Rooney W, Clifton A, Kosmidis M H, Breier A, Pickar D

Abstract excerpt

Several lines of evidence suggest that the dopamine D3 receptor is involved in the pathophysiology of schizophrenia. The D3 receptor gene (DRD3) contains a polymorphism resulting in a serine-glycine substitution in the N-terminus of the receptor. Shaikh and colleagues have reported a significant association between the DRD3 Ser9 allele and the Ser9/Ser9 genotype with schizophrenia in 133 Caucasians. In a...

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Source

Identifiers

PMID: 9491816
DOI: 10.1038/sj.mp.4000288

Genes

DRD3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The dopamine D3 receptor (DRD3) Ser9Gly polymorphism and schizophrenia: a haplotype relative risk study and association with clozapine response.PMID 9491816Read ↗

The Ser9Gly polymorphism of the dopamine D3 receptor gene and risk of schizophrenia: an association study and a large meta-analysis.Semantic proximity Read ↗

Effect of dopamine D3 receptor gene polymorphisms and clozapine treatment response: exploratory analysis of nine polymorphisms and meta-analysis of the Ser9Gly variant.Semantic proximity Read ↗

Further evidence of no association between Ser9Gly polymorphism of dopamine D3 receptor gene and schizophrenia.Semantic proximity Read ↗

No association between the DRD3 Ser9Gly polymorphism and schizophrenia.Semantic proximity Read ↗

Dopamine D3 receptor gene Ser9Gly variant and schizophrenia: association study and meta-analysis.Semantic proximity Read ↗

Meta-analysis of the dopamine D3 receptor gene (DRD3) Ser9Gly variant and schizophrenia.Semantic proximity Read ↗

No association between the Ser9Gly polymorphism of the dopamine D3 receptor gene and schizophrenia in a Spanish sample.Semantic proximity Read ↗

Investigation of possible association between Ser9Gly polymorphism of the D3 dopaminergic receptor gene and response to typical antipsychotics in patients with schizophrenia.Semantic proximity Read ↗

DRD3 Ser9Gly polymorphism and treatment response to antipsychotics in schizophrenia: A meta-analysis.Semantic proximity Read ↗

Allelic association between a Ser-9-Gly polymorphism in the dopamine D3 receptor gene and schizophrenia.Semantic proximity Read ↗

Dopamine D3 receptor Gly9/Ser9 polymorphism and schizophrenia: no increased frequency of homozygosity in German familial cases.Semantic proximity Read ↗

Genetic association between the dopamine D3 gene polymorphism (Ser9Gly) and schizophrenia in Japanese populations: evidence from a case-control study and meta-analysis.Semantic proximity Read ↗

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