Article

Genetic ablation of adhesion ligands averts rejection of allogeneic immune cells

2023-10-09

Abstract excerpt

<h4>SUMMARY</h4> Allogeneic cell therapies hold promise for broad clinical implementation, but face limitations due to potential rejection by the recipient immune system. Silencing of beta-2-microglobulin ( B2M ) expression is commonly employed to evade T cell-mediated rejection, although absence of B2M triggers missing-self responses by recipient natural killer (NK) cells. Here, we demonstrate that deletion of...

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Literature Corpus work: cc940c1c-ecef-5f8e-a4d6-c64522898aab
DOI: 10.1101/2023.10.09.557143

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