Article
Interleukin-8 receptor beta. The role of the carboxyl terminus in signal transduction.
The Journal of biological chemistry - 21 Apr 1995
Ben-Baruch A, Bengali K M, Biragyn A, Johnston J J, Wang J M, Kim J, Chuntharapai A, Michiel D F, Oppenheim J J, Kelvin D J
Abstract excerpt
Two interleukin-8 (IL-8) receptors, alpha and beta, have been identified and cloned. Both receptors are thought to transduce signals by coupling to GTP-binding proteins. The aim of this study is to determine whether the carboxyl terminus (C') of IL-8 receptor beta (IL-8R beta) is involved in signaling in response to IL-8. We have constructed a number of IL-8R beta genes that encode truncated forms of the IL-8R...
Topics
- Chemotaxis
- Humans
- Interleukin-8
- Mutation
- Receptors, Interleukin
- Receptors, Interleukin-8A
- Signal Transduction
- Structure-Activity Relationship
- Transfection