Article
Analysis of the leukemia inhibitory factor receptor functional domains by chimeric receptors and cytokines.
Biochemistry - 13 May 2003
Aasland Dorthe, Schuster Björn, Grötzinger Joachim, Rose-John Stefan, Kallen Karl-Josef
Abstract excerpt
In contrast to other hematopoietic cytokine receptors, the leukemia inhibitory factor receptor (LIFR) possesses two cytokine binding modules (CBMs). Previous studies suggested that the NH(2)-terminal CBM and the Ig-like domain of the LIFR are most important for LIF binding and activity. Using the recently engineered designer cytokine IC7, which induces an active heterodimer of the LIFR and gp130 after binding to...
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