Article
Structure and function of the intracellular portion of the mouse interleukin 1 receptor (type I). Determining the essential region for transducing signals to activate the interleukin 8 gene.
The Journal of biological chemistry - 25 Jun 1993
Kuno K, Okamoto S, Hirose K, Murakami S, Matsushima K
Abstract excerpt
The structural and functional relationships of the intracellular portion of mouse interleukin 1 receptor (muIL-1R) type I were examined with regard to activation of the human IL-8 gene in the Jurkat T cell line. C-terminal deletion mutations of muIL-1R revealed that the C-terminal boundary for receptor function is localized between 28 and 42 amino acids from the C-terminal end. The internal deletion mutants...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- CHO Cells
- Cricetinae
- DNA
- Gene Expression Regulation
- Humans
- Interleukin-8
- Mice
- Molecular Sequence Data