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Article

Structure and function of chicken interleukin-1 beta mutants: uncoupling of receptor binding and in vivo biological activity.

Scientific reports - 9 Jun 2016

Chen Wen-Ting, Huang Wen-Yang, Chen Ting, Salawu Emmanuel Oluwatobi, Wang Dongli, Lee Yi-Zong, Chang Yuan-Yu, Yang Lee-Wei, Sue Shih-Che, Wang Xinquan, Yin Hsien-Sheng

Abstract excerpt

Receptor-binding and subsequent signal-activation of interleukin-1 beta (IL-1β) are essential to immune and proinflammatory responses. We mutated 12 residues to identify sites important for biological activity and/or receptor binding. Four of these mutants with mutations in loop 9 (T117A, E118K, E118A, E118R) displayed significantly reduced biological activity. Neither T117A nor E118K mutants substantially...

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Identifiers

PMID: 27278931
DOI: 10.1038/srep27729
PMCID: PMC4899739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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