Article
Inhibition of granulocyte-macrophage colony-stimulating factor receptor function by a splice variant of the common beta-receptor subunit.
Blood - 1 Nov 2001
Wagner K, Kafert-Kasting S, Heil G, Ganser A, Eder M
Abstract excerpt
The receptors for human granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 are composed of a ligand-specific alpha-chain (eg, alpha-GM-CSF receptor [alpha-GMR]) and a common beta-subunit (beta-GMR). Ligand binding is believed to induce assembly or conformational changes in preformed complexes containing more than one alpha- and beta-subunit in the activated receptor complex....
Topics
- Alternative Splicing
- Animals
- Cell Line
- Cell Survival
- Frameshift Mutation
- Gene Expression Regulation
- Genetic Variation
- Granulocyte-Macrophage Colony-Stimulating Factor
- Humans
- Mice
- Protein Subunits
- Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
- Recombinant Fusion Proteins