Identification of two regions within the cytoplasmic domain of the human interferon-gamma receptor required for function.

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Article

Identification of two regions within the cytoplasmic domain of the human interferon-gamma receptor required for function.

The Journal of biological chemistry - 15 Oct 1991

Farrar M A, Fernandez-Luna J, Schreiber R D

Abstract excerpt

Functionally active human interferon-gamma (IFN gamma) receptors require the presence of at least two polypeptides: the IFN gamma receptor and an accessory molecule encoded by a gene on human chromosome 21. Here we have used a murine L cell line that stably contains human chromosome 21 (SCC16-5) to determine whether the receptor's cytoplasmic domain is important for receptor function. SCC16-5 stably transfected...

Topics

Animals
Base Sequence
Chromosomes, Human, Pair 21
DNA
Flow Cytometry
Genes, MHC Class I
Humans
Interferons
L Cells
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Polymerase Chain Reaction

Precipitin Tests

Receptors, Immunologic

Receptors, Interferon

Recombinant Proteins

Transfection

Source

Open in PubMed

Identifiers

PMID: 1717469

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1717469-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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