Article
Tyrosine 706 and 807 phosphorylation site mutants in the murine colony-stimulating factor-1 receptor are unaffected in their ability to bind or phosphorylate phosphatidylinositol-3 kinase but show differential defects in their ability to induce early response gene transcription.
Molecular and cellular biology - 1 Sept 1991
van der Geer P, Hunter T
Abstract excerpt
The receptor for colony-stimulating factor-1 (CSF-1) is a receptor protein-tyrosine kinase. To study the possible function of CSF-1 receptor autophosphorylation, two autophosphorylation sites, Tyr-706, located in the kinase insert, and Tyr-807, a residue conserved in all protein-tyrosine kinases,...
Topics
- 1-Phosphatidylinositol 4-Kinase
- Animals
- Base Sequence
- Cell Division
- Cells, Cultured
- DNA
- Gene Expression Regulation
- Mice
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Peptide Mapping
- Phosphorylation