Article
Regulation of human interleukin-8 receptor A: identification of a phosphorylation site involved in modulating receptor functions.
Biochemistry - 31 Oct 1995
Richardson R M, DuBose R A, Ali H, Tomhave E D, Haribabu B, Snyderman R
Abstract excerpt
The human type A interleukin-8 receptor (IL-8RA) was modified to express an amino-terminal epitope tag and stably overexpressed in a rat basophilic leukemia cell line (RBL-2H3). This receptor (ET-IL-8RA) displayed functional properties similar to those of the native receptor in neutrophils in that exposure to IL-8 stimulated GTPase activity, phosphoinositide (PI) hydrolysis, intracellular calcium mobilization,...
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