Regulation of human interleukin-8 receptor A: identification of a phosphorylation site involved in modulating receptor functions.

doi:10.1021/bi00043a025

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Regulation of human interleukin-8 receptor A: identification of a phosphorylation site involved in modulating receptor functions.

Biochemistry - 31 Oct 1995

Richardson R M, DuBose R A, Ali H, Tomhave E D, Haribabu B, Snyderman R

Abstract excerpt

The human type A interleukin-8 receptor (IL-8RA) was modified to express an amino-terminal epitope tag and stably overexpressed in a rat basophilic leukemia cell line (RBL-2H3). This receptor (ET-IL-8RA) displayed functional properties similar to those of the native receptor in neutrophils in that exposure to IL-8 stimulated GTPase activity, phosphoinositide (PI) hydrolysis, intracellular calcium mobilization,...

Topics

Alkaloids
Amino Acid Sequence
Animals
Antigens, CD
Binding Sites
DNA, Complementary
Epitopes
Humans
Interleukin-8
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphorylation

Precipitin Tests

Protein Kinase C

Rats

Receptors, Interleukin

Receptors, Interleukin-8A

Serine

Source

Open in PubMed

Identifiers

PMID: 7578017
DOI: 10.1021/bi00043a025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7578017-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of human interleukin-8 receptor A: identification of a phosphorylation site involved in modulating receptor functions.PMID 7578017Read ↗

Regulation of N-formyl peptide receptor signaling and trafficking by individual carboxyl-terminal serine and threonine residues.Semantic proximity Read ↗

LPA3 Receptor Phosphorylation Sites: Roles in Signaling and Internalization.Semantic proximity Read ↗

Serine 331 is major site of phosphorylation and desensitization induced by protein kinase C in thromboxane receptor alpha.Semantic proximity Read ↗

Multiple sites on IL-8 responsible for binding to alpha and beta IL-8 receptors.Semantic proximity Read ↗

Identification of a Ser/Thr cluster in the C-terminal domain of the human prostaglandin receptor EP4 that is essential for agonist-induced beta-arrestin1 recruitment but differs from the apparent principal phosphorylation site.Semantic proximity Read ↗

alpha-Chain phosphorylation of the human leukocyte CD11b/CD18 (Mac-1) integrin is pivotal for integrin activation to bind ICAMs and leukocyte extravasation.Semantic proximity Read ↗

Activation of STAT6 is not dependent on phosphotyrosine-mediated docking to the interleukin-4 receptor and can be blocked by dominant-negative mutants of both receptor subunits.Semantic proximity Read ↗

Phosphorylation-independent beta-arrestin translocation and internalization of leukotriene B4 receptors.Semantic proximity Read ↗

Immunoprecipitation and phosphorylation of G protein-coupled receptors.Semantic proximity Read ↗

Interleukin-8 receptor beta. The role of the carboxyl terminus in signal transduction.Semantic proximity Read ↗

Identification and characterization of the phosphorylation sites of the guanylyl cyclase-linked natriuretic peptide receptors A and B.Semantic proximity Read ↗

Structure-function studies of the C3a-receptor: C-terminal serine and threonine residues which influence receptor internalization and signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.