The absence of ongoing immunoglobulin gene hypermutation suggests a distinct mechanism for c-myc mutation in endemic Burkitt's lymphoma.

doi:10.1097/00043426-199602000-00006

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Article

The absence of ongoing immunoglobulin gene hypermutation suggests a distinct mechanism for c-myc mutation in endemic Burkitt's lymphoma.

Journal of pediatric hematology/oncology - 1 Feb 1996

Cowley C G, Carroll W L, Johnston J M

Abstract excerpt

PURPOSE: Burkitt's lymphoma is a malignancy of mature, immunoglobulin (Ig)-bearing B cells characterized by translocation between c-myc and Ig gene loci. A role for the juxtaposed Ig genes in the mutation and deregulation of c-myc expression typical of endemic Burkitt's lymphoma (eBL) has been pr...

Topics

Base Sequence
Burkitt Lymphoma
DNA Mutational Analysis
DNA-Directed DNA Polymerase
Genes, Immunoglobulin
Genes, myc
Humans
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
RNA, Neoplasm
RNA-Directed DNA Polymerase
Taq Polymerase
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 8556366
DOI: 10.1097/00043426-199602000-00006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8556366-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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