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Article

Low rate of somatic hypermutations characterize progressive B-cell lymphomas.

European journal of haematology - 1 Sept 1998

Rosenquist R, Lindström A, Li A H, Roos G, Lindh J, Holmberg D

Abstract excerpt

Immunoglobulin heavy (IgH) chain gene rearrangements were characterized in 40 samples from 15 patients with B-cell lymphomas at different time points during tumour progression. Using polymerase chain reaction (PCR) amplification and single strand conformation polymorphism (SSCP) analysis of variable heavy (VH) chain gene segments, we found that 6 cases displayed alterations in their IgH chain rearrangements at...

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Identifiers

PMID: 9753412
DOI: 10.1111/j.1600-0609.1998.tb01080.x

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