Article
The second-site mutation in the herpes simplex virus recombinants lacking the gamma134.5 genes precludes shutoff of protein synthesis by blocking the phosphorylation of eIF-2alpha.
Journal of virology - 1 Sept 1998
Cassady K A, Gross M, Roizman B
Abstract excerpt
In cells infected with the herpes simplex virus 1 (HSV-1) recombinant R3616 lacking both copies of the gamma134.5 gene, the double-stranded protein kinase R (PKR) is activated, eIF-2alpha is phosphorylated, and protein synthesis is shut off. Although PKR is also activated in cells infected with t...
Topics
- Animals
- Capsid
- Capsid Proteins
- Cell Differentiation
- Chlorocebus aethiops
- Eukaryotic Initiation Factor-2
- Gene Deletion
- Genes, Viral
- Genotype
- HeLa Cells
- Herpesvirus 1, Human
- Humans
- Mutagenesis, Insertional
- Mutation
- Phosphoproteins