Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Herpes Simplex Virus-1 Transactivator Infected Cell Protein-4 Drives VEGF-A Dependent Neovascularization

6 Oct 2011

Abstract excerpt

Herpes simplex virus-1 (HSV-1) causes lifelong infection affecting between 50 and 90% of the global population. In addition to causing dermal lesions, HSV-1 is a leading cause of blindness resulting from recurrent corneal infection. Corneal disease is characterized by loss of corneal immunologic privilege and extensive neovascularization driven by vascular endothelial growth factor-A (VEGF-A). In the current...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Herpesvirus Infections and Treatments
Share to Ocular Infections and Treatments
Share to Ocular Surface and Contact Lens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21998580
DOI: 10.1371/journal.ppat.1002278

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Herpes Simplex Virus-1 Transactivator Infected Cell Protein-4 Drives VEGF-A Dependent NeovascularizationPMID 21998580Read ↗

Transcriptional consequences of herpes simplex virus 1 ICP4 inducible expression in uninfected cellsSemantic proximity Read ↗

ICP4-induced miR-101 attenuates HSV-1 replicationSemantic proximity Read ↗

Herpes Simplex Virus Disrupts NF-κB Regulation by Blocking Its Recruitment on the IκBα Promoter and Directing the Factor on Viral GenesSemantic proximity Read ↗

The Herpes Simplex Virus ICP0 RING Finger Domain Inhibits IRF3- and IRF7-Mediated Activation of Interferon-Stimulated GenesSemantic proximity Read ↗

The Many Roles of the Highly Interactive HSV Protein ICP27, A Key Regulator of InfectionSemantic proximity Read ↗

The Herpes Simplex Virus 1 Protein ICP4 Acts as both an Activator and a Repressor of Host Genome Transcription during InfectionSemantic proximity Read ↗

The key genes involved in herpes simplex virus-1 corneal infection-induced acute hepatitisSemantic proximity Read ↗

Herpes simplex virus-induced upregulation of inflammatory cytokines in human gingival fibroblastsSemantic proximity Read ↗

Induction of IL-6 in Transcriptional Networks in Corneal Epithelial Cells after Herpes Simplex Virus Type 1 InfectionSemantic proximity Read ↗

Hidden regulation of herpes simplex virus 1 pre-mRNA splicing and polyadenylation by virally encoded immediate early gene ICP27Semantic proximity Read ↗

VEGF Upregulation in Viral Infections and Its Possible Therapeutic ImplicationsSemantic proximity Read ↗

Widespread activation of antisense transcription of the host genome during herpes simplex virus 1 infectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.