Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational analysis of the promoter region of the alpha 27 gene of herpes simplex virus 1 within the context of the viral genome.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1990

Spector D, Purves F, Roizman B

Abstract excerpt

In herpes simplex virus 1-infected cells, the first set of genes to be expressed (alpha genes) is induced by the alpha gene trans-inducing factor (alpha TIF), a virion structural protein. The cis-acting site in the 5' untranscribed domain of alpha genes was previously reported to be the sequence 5'-GYATGNTAATGARATTCYTTGNGGG noncoding (where Y is a pyrimidine, R is a purine, N is any base), which binds a host...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Cloning, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Viral

Share to Molecular Sequence Data

Share to Mutation

Share to Promoter Regions, Genetic

Share to Restriction Mapping

Share to Vero Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 2164672
DOI: 10.1073/pnas.87.14.5268
PMCID: PMC54304

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational analysis of the promoter region of the alpha 27 gene of herpes simplex virus 1 within the context of the viral genome.PMID 2164672Read ↗

Protein and DNA elements involved in transactivation of the promoter of the bovine herpesvirus (BHV) 1 IE-1 transcription unit by the BHV alpha gene trans-inducing factorSemantic proximity Read ↗

The bovine herpesvirus alpha gene trans-inducing factor activates transcription by mechanisms different from those of its herpes simplex virus type 1 counterpart VP16Semantic proximity Read ↗

Repression of the herpes simplex virus 1 alpha 4 gene by its gene product (ICP4) within the context of the viral genome is conditioned by the distance and stereoaxial alignment of the ICP4 DNA binding site relative to the TATA box.Semantic proximity Read ↗

The phenotype in vitro and in infected cells of herpes simplex virus 1 alpha trans-inducing factor (VP16) carrying temperature-sensitive mutations introduced by substitution of cysteines.Semantic proximity Read ↗

Transcription of alpha-specific genes in Saccharomyces cerevisiae: DNA sequence requirements for activity of the coregulator alpha 1.Semantic proximity Read ↗

Functional modules important for activated expression of early genes of herpes simplex virus type 1 are clustered upstream of the TATA box.Semantic proximity Read ↗

Herpes simplex virus infections are arrested in Oct-1-deficient cellsSemantic proximity Read ↗

Activation of RNA Polymerase III Transcription of Human Alu Elements by Herpes Simplex VirusSemantic proximity Read ↗

Genetic evidence for two distinct transactivation functions of the herpes simplex virus alpha protein ICP27.Semantic proximity Read ↗

Amino acid substitutions in the herpes simplex virus transactivator VP16 uncouple direct protein-protein interaction and DNA binding from complex assembly and transactivation.Semantic proximity Read ↗

The human alpha subunit glycoprotein hormone gene utilizes a unique CCAAT binding factor.Semantic proximity Read ↗

Mutational analysis of a transcriptional activation region of the VP16 protein of herpes simplex virus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.