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Article

Functional genomic analysis of herpes simplex virus type 1 counteraction of the host innate response.

Journal of virology - 1 Aug 2006

Pasieka Tracy Jo, Baas Tracey, Carter Victoria S, Proll Sean C, Katze Michael G, Leib David A

Abstract excerpt

Herpes simplex virus type 1 (HSV-1) mutants lacking the ICP34.5 gene are severely attenuated in mouse models and have a significant growth defect in confluent mouse embryo fibroblasts. Previously, ICP34.5 was demonstrated to have a crucial role in evading the innate immune response to infection by mediating the dephosphorylation of eIF2alpha, a translation initiation factor phosphorylated by PKR during the...

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Identifiers

PMID: 16840339
DOI: 10.1128/JVI.00333-06
PMCID: PMC1563739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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