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The herpes simplex virus regulatory protein ICP27 contributes to the decrease in cellular mRNA levels during infection

1 Aug 1994

Abstract excerpt

We have previously shown that the herpes simplex virus immediate-early regulatory protein ICP27 acts posttranscriptionally to affect mRNA processing (R. M. Sandri-Goldin and G. E. Mendoza, Genes Dev. 6:848-863, 1992). Specifically, in the presence of ICP27, spliced target mRNAs were decreased 5- to 10-fold in transfections with target genes containing a 5' or 3' intron. Here, we have investigated the effect of...

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PMID: 8035480
DOI: 10.1128/jvi.68.8.4797-4810.1994

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