Binding sites for the herpes simplex virus immediate-early protein ICP4 impose an increased dependence on viral DNA replication on simple model promoters located in the viral genome.

doi:10.1128/JVI.67.12.7254-7263.1993

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Article

Binding sites for the herpes simplex virus immediate-early protein ICP4 impose an increased dependence on viral DNA replication on simple model promoters located in the viral genome.

Journal of virology - 1 Dec 1993

Koop K E, Duncan J, Smiley J R

Abstract excerpt

We examined the ability of binding sites for the herpes simplex virus immediate-early protein ICP4 to alter the regulation of closely linked promoters by placing strong ICP4 binding sites upstream or downstream of simple TATA promoters in the intact viral genome. We found that binding sites strongly reduced the levels of expression at early times postinfection and that this effect was partially overcome after the...

Topics

Animals
Aphidicolin
Base Sequence
DNA Replication
DNA, Recombinant
Genome, Viral
Glutathione Transferase
Herpesvirus 1, Human
Immediate-Early Proteins
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Promoter Regions, Genetic

Recombinant Fusion Proteins

TATA Box

Transcription, Genetic

Vero Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 8230448
DOI: 10.1128/JVI.67.12.7254-7263.1993
PMCID: PMC238188

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8230448-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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