Article
Expression of transfected transforming growth factor alpha induces a motile fibroblast-like phenotype with extracellular matrix-degrading potential in a rat bladder carcinoma cell line.
Cell regulation - 1 Dec 1990
Gavrilović J, Moens G, Thiery J P, Jouanneau J
Abstract excerpt
Acquisition of cell motility is often correlated with the malignant progression of a transformed cell. To investigate some of the mechanisms involved in the development of a migratory state, we transfected the NBTII rat carcinoma cell line, which forms stationary epithelial clusters in culture, w...
Topics
- Animals
- Blotting, Northern
- Cell Differentiation
- Cell Line, Transformed
- Extracellular Matrix
- Fibroblasts
- Metalloendopeptidases
- Phenotype
- Plasminogen Activators
- RNA, Messenger
- Rats
- Transfection
- Transforming Growth Factors
- Urinary Bladder Neoplasms
- Vimentin