Article
Polymorphisms in the human DNA polymerase beta gene.
Human genetics - 1 Apr 1995
Dobashi Y, Kubota Y, Shuin T, Torigoe S, Yao M, Hosaka M
Abstract excerpt
Recently, evidence has accumulated that mutations in DNA repair genes might be associated with certain steps in carcinogenesis. The DNA polymerase beta gene is one of the DNA repair genes, and mutations in it have been detected in 83% of human colorectal cancers. To assess the involvement of poly...
Topics
- Base Sequence
- Colorectal Neoplasms
- DNA Polymerase I
- DNA, Neoplasm
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Prostatic Neoplasms
- RNA, Neoplasm
- Tumor Cells, Cultured