Article
[Research progress on DNA polymerase beta and genetic instability].
Wei sheng yan jiu = Journal of hygiene research - 1 Sept 2009
Wu Mei, Zhang Zunzhen
Abstract excerpt
DNA polymerase beta (pol beta), a predominant enzyme involved in DNA base excision repair (BER), plays an important role in repair of DNA damage and maintaining stability and integrality of genome. Pol beta lacks 3' to 5' proofreading activity, which contributes to its low fidelity in DNA synthesis. There are different results about action rule of pol beta in genetic instability and mechanism of pol beta in...
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