Article
DNA polymerase beta gene mutation in human prostate cancer.
Cancer research - 1 Jun 1994
Dobashi Y, Shuin T, Tsuruga H, Uemura H, Torigoe S, Kubota Y
Abstract excerpt
DNA polymerase beta is a nuclear protein essential to DNA repair in mammalian cells. A high frequency of mutations in this gene has been reported in colorectal cancers. To clarify the tumorigenesis steps of human prostate cancers in the molecular basis, we examined the entire coding region of the human DNA polymerase beta gene in human prostate cancer tissues using polymerase chain reaction, single-strand...
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