Article
Functional mutation of DNA polymerase beta found in human gastric cancer--inability of the base excision repair in vitro.
Mutation research - 22 Oct 1999
Iwanaga A, Ouchida M, Miyazaki K, Hori K, Mukai T
Abstract excerpt
DNA polymerase beta (polbeta) is one of mammalian DNA polymerases and is known to be involved in a G:T/G:U mismatch repair. In order to investigate an involvement of this enzyme in a base excision repair, we searched a mutation of human polbeta in human gastric cancer and studied a function of the mutation. We observed cancer-specific missense mutations in 6 of 20 samples. All of these mutations were, however,...
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