Article
The apolipoprotein E epsilon4 allele causes a faster decline of cognitive performances in Down's syndrome subjects.
Journal of the neurological sciences - 1 Jan 1997
Del Bo R, Comi G P, Bresolin N, Castelli E, Conti E, Degiuli A, Ausenda C D, Scarlato G
Abstract excerpt
The apolipoprotein E gene (APOE), located on human chromosome 19, has three common alleles (epsilon2, epsilon3, epsilon4) which encode for the three main isoforms indicated as E2, E3 and E4 respectively. Several findings indicate epsilon4 allele as an important risk factor in both sporadic and fa...
Topics
- Adolescent
- Adult
- Alleles
- Amyloid
- Apolipoprotein E4
- Apolipoproteins E
- Child
- Child, Preschool
- Cognition Disorders
- Disease Progression
- Down Syndrome
- Genotype
- Humans
- Infant
- Mutation
- Neuropsychological Tests