Altered fibronectin-dependent cell adhesion by PDGF accompanies phenotypic modulation of vascular smooth muscle cells.

doi:10.1006/bbrc.1993.2348

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Article

Altered fibronectin-dependent cell adhesion by PDGF accompanies phenotypic modulation of vascular smooth muscle cells.

Biochemical and biophysical research communications - 29 Oct 1993

Fujio Y, Yamada F, Takahashi K, Shibata N

Abstract excerpt

PDGF promotes growth of smooth muscle cells (SMCs) and induces morphological changes. We investigated the effects of PDGF on cell-matrix adhesion of SMCs. PDGF reorganized integrin distribution as well as actin filament structure. PDGF-treated cells attached more loosely to fibronectin than non-treated cells. Decreased expression of alpha-actin by PDGF was antagonized by coating culture dishes with fibronectin...

Topics

Actins
Animals
Cell Adhesion
Cell Line
Dose-Response Relationship, Drug
Extracellular Matrix
Fibronectins
Glycoproteins
Humans
Kinetics
Laminin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscle, Smooth, Vascular

Oligopeptides

Phenotype

Platelet-Derived Growth Factor

Pulmonary Artery

Rats

Recombinant Proteins

Source

Open in PubMed

Identifiers

PMID: 7694583
DOI: 10.1006/bbrc.1993.2348

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7694583-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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