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Article

Fibronectin matrix polymerization regulates smooth muscle cell phenotype through a Rac1 dependent mechanism.

PloS one - 1 Jan 2014

Shi Feng, Long Xiaochun, Hendershot Allison, Miano Joseph M, Sottile Jane

Abstract excerpt

Smooth muscle cells are maintained in a differentiated state in the vessel wall, but can be modulated to a synthetic phenotype following injury. Smooth muscle phenotypic modulation is thought to play an important role in the pathology of vascular occlusive diseases. Phenotypically modulated smooth muscle cells exhibit increased proliferative and migratory properties that accompany the downregulation of smooth...

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Identifiers

PMID: 24752318
DOI: 10.1371/journal.pone.0094988
PMCID: PMC3994013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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