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Article

PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns.

American journal of physiology. Heart and circulatory physiology - 1 Feb 2009

Thomas James A, Deaton Rebecca A, Hastings Nicole E, Shang Yueting, Moehle Christopher W, Eriksson Ulf, Topouzis Stavros, Wamhoff Brian R, Blackman Brett R, Owens Gary K

Abstract excerpt

Platelet-derived growth factor (PDGF)-BB is a well-known smooth muscle (SM) cell (SMC) phenotypic modulator that signals by binding to PDGF alphaalpha-, alphabeta-, and betabeta-membrane receptors. PDGF-DD is a recently identified PDGF family member, and its role in SMC phenotypic modulation is unknown. Here we demonstrate that PDGF-DD inhibited expression of multiple SMC genes, including SM alpha-actin and SM...

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Identifiers

PMID: 19028801
DOI: 10.1152/ajpheart.00165.2008
PMCID: PMC2643880

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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