Article
Control of smooth muscle cell proliferation and phenotype by integrin signaling through focal adhesion kinase.
Biochemical and biophysical research communications - 27 May 2000
Morla A O, Mogford J E
Abstract excerpt
Extracellular matrix proteins such as fibronectin (FN) and laminin (LM) are known to help control the growth and phenotype of vascular smooth muscle cells (VSMCs). Here we have analyzed the relationship between growth factor and integrin signaling pathways in VSMCs. Culturing porcine coronary artery smooth muscle cells (PCASMCs) on FN and LM leads to distinct effects on cell proliferation and contractile protein...
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