Article
Type I collagen promotes modulation of cultured rabbit arterial smooth muscle cells from a contractile to a synthetic phenotype.
Experimental cell research - 1 Jan 1993
Yamamoto M, Yamamoto K, Noumura T
Abstract excerpt
The phenotypic transition of smooth muscle cells (SMC) from a contractile to a synthetic state appears to be an early event in the pathogenesis of atherosclerosis. We examined the effects of extracellular matrix components on the phenotypic modulation of rabbit arterial SMC in primary culture by...
Topics
- Amino Acid Sequence
- Animals
- Cell Adhesion
- Cell Division
- Cells, Cultured
- Collagen
- Flow Cytometry
- Immunohistochemistry
- Male
- Microscopy, Phase-Contrast
- Molecular Sequence Data
- Muscle Contraction
- Muscle, Smooth, Vascular
- Peptides
- Phenotype
- Rabbits
- Time Factors