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Article

Role of tyrosine kinases in extracellular matrix-mediated modulation of arterial smooth muscle cell phenotype.

Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 1997

Hedin U, Thyberg J, Roy J, Dumitrescu A, Tran P K

Abstract excerpt

Fibronectin (FN) promotes the modulation of freshly isolated arterial smooth muscle cells (SMCs) from a contractile to a synthetic phenotype by interacting with integrins on the cell surface. This process is characterized by a structural and functional transformation of the cells, including a reorganization of the cytoskeleton, the formation of a large secretory apparatus, and the acquisition of proliferative...

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Source

Identifiers

PMID: 9351362
DOI: 10.1161/01.atv.17.10.1977

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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