Article
Role of tyrosine kinases in extracellular matrix-mediated modulation of arterial smooth muscle cell phenotype.
Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 1997
Hedin U, Thyberg J, Roy J, Dumitrescu A, Tran P K
Abstract excerpt
Fibronectin (FN) promotes the modulation of freshly isolated arterial smooth muscle cells (SMCs) from a contractile to a synthetic phenotype by interacting with integrins on the cell surface. This process is characterized by a structural and functional transformation of the cells, including a reo...
Topics
- Actins
- Animals
- Cell Adhesion Molecules
- Extracellular Matrix
- Focal Adhesion Kinase 1
- Focal Adhesion Protein-Tyrosine Kinases
- Genistein
- Male
- Muscle, Smooth, Vascular
- Phenotype
- Phosphorylation
- Phosphotyrosine
- Protein-Tyrosine Kinases
- Rats
- Rats, Sprague-Dawley