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Article

RhoA/ROCK signaling regulates smooth muscle phenotypic modulation and vascular remodeling via the JNK pathway and vimentin cytoskeleton.

Pharmacological research - 1 Jul 2018

Tang Lian, Dai Fan, Liu Yan, Yu Xiaoqiang, Huang Chao, Wang Yuqin, Yao Wenjuan

Abstract excerpt

The RhoA/ROCK signaling pathway regulates cell morphology, adhesion, proliferation, and migration. In this study, we investigated the regulatory role of RhoA/ROCK signaling on PDGF-BB-mediated smooth muscle phenotypic modulation and vascular remodeling and clarified the molecular mechanisms behind these effects. PDGF-BB treatment induced the activation of RhoA, ROCK, PDGF-Rβ, and the expression of PDGF-Rβ in...

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Source

Identifiers

PMID: 29791873
DOI: 10.1016/j.phrs.2018.05.011

Genes

ROCK1
ROCK2
CDK2
CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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