Article
Patterns of gene expression differentially regulated by platelet-derived growth factor and hypertrophic stimuli in vascular smooth muscle cells: markers for phenotypic modulation and response to injury.
The Journal of biological chemistry - 20 May 2005
Kaplan-Albuquerque Nihal, Bogaert Yolanda E, Van Putten Vicki, Weiser-Evans Mary C, Nemenoff Raphael A
Abstract excerpt
In vascular smooth muscle cells (VSMC), platelet-derived growth factor (PDGF) suppresses expression of multiple smooth muscle contractile proteins, useful markers of differentiation. Conversely, hypertrophic agents induce expression of these genes. The goal of this study was to employ genomic approaches to identify classes of genes differentially regulated by PDGF and hypertrophic stimuli. Changes in gene...
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