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Article

Integrin α9 regulates smooth muscle cell phenotype switching and vascular remodeling.

JCI insight - 24 May 2021

Jain Manish, Dev Rishabh, Doddapattar Prakash, Kon Shigeyuki, Dhanesha Nirav, Chauhan Anil K

Abstract excerpt

Excessive proliferation of vascular smooth muscle cells (SMCs) remains a significant cause of in-stent restenosis. Integrins, which are heterodimeric transmembrane receptors, play a crucial role in SMC biology by binding to the extracellular matrix protein with the actin cytoskeleton within the SMC. Integrin α9 plays an important role in cell motility and autoimmune diseases; however, its role in SMC biology and...

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Identifiers

PMID: 34027892
DOI: 10.1172/jci.insight.147134
PMCID: PMC8262341

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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