Article
An improved estimator of spontaneous mutation rates in Luria-Delbrück fluctuation experiments.
Mutation research - 1 Oct 1993
Jones M E
Abstract excerpt
In estimating the spontaneous mutation rate, mu, in cultured mammalian cells, the number of mutant cells in several parallel cultures, each a clone from a single cell, is determined. Luria and Delbrück (1943), and subsequently Lea and Coulson (1949), proposed several estimators of mu using data from such experiments. These methods of analysis were originally proposed to apply to mutants arising in microbial...
Topics
- Algorithms
- Animals
- Cells, Cultured
- Likelihood Functions
- Mammals
- Mutation