Luria-Delbrück fluctuation experiments; accounting simultaneously for plating efficiency and differential growth rate.

Abstract excerpt

Cells growing in culture are subject to mutation, and as mutation is a random event, the number of mutants in a culture will be a random variable. The size of the clone of mutants arising from a single mutational event depends on the timing of the mutation; the earlier the mutation the larger the corresponding clone of mutants. The frequency with which new mutations arise may be estimated from examining the...

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