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Article

Measuring Mutation Rates Using the Luria-Delbrück Fluctuation Assay.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018

Lang Gregory I

Abstract excerpt

The Luria-Delbrück fluctuation assay is one of the most commonly used methods for measuring the mutation rate in microorganisms. Specifically, it is used to measure the mutation rate at a particular locus or loci at which mutations give rise to a selectable phenotype. Here, I outline the essential features of performing Luria-Delbrück fluctuation assays as well as common missteps and tips for improving the...

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PMID: 29043614
DOI: 10.1007/978-1-4939-7306-4_3

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