Article
A note on efficient estimation of mutation rates using Luria-Delbrück fluctuation analysis.
Mutation research - 1 Jul 1991
Koziol J A
Abstract excerpt
The maximum likelihood and Luria-Delbrück P0 methods for the estimation of spontaneous mutation rates are compared. The maximum likelihood method is fully efficient, utilizing all available information in a fluctuation experiment, but can be numerically cumbersome. Under certain conditions, there is little loss of efficiency using the P0 method, which is readily implemented numerically. Design considerations...
Topics
- Mathematics
- Models, Statistical
- Mutation