Article
A note on the evaluation of fluctuation experiments.
Mutation research - 8 Aug 2001
Angerer W P
Abstract excerpt
Fluctuation analysis has emerged as a valuable tool for the measurement of mutation rates in single-cell populations. In this paper, we show how to make fuller use of the information supplied by the outcome of a fluctuation experiment. We shall extend Lea and Coulson's theory of the Luria-Delbrück distribution so that it accounts for residual mutation, reduced plating efficiency of mutants, and phenotypic lag,...
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