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Article

Mutations and infinity: improved statistical methods for estimating spontaneous rates.

Environmental and molecular mutagenesis - 1 Jan 1996

Nádas A, Goncharova E I, Rossman T G

Abstract excerpt

Certain mathematical artifacts which had been appended by others to Luria and Delbrück's [Genetics 28: 491-511, 1943] model of spontaneous mutagenesis in bacterial populations have added confusion to the modeling and measurement of spontaneous mutation rates. Additional confusion arises when models which had been tuned for experiments with bacterial cultures grown from a small inoculum are adapted for use with...

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PMID: 8844989
DOI: 10.1002/(SICI)1098-2280(1996)28:2<90::AID-EM4>3.0.CO;2-I

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