Article
A robust estimator of mutation rates.
Mutation research - 10 Feb 2009
Wu Xiaowei, Strome Erin D, Meng Qingchang, Hastings Philip J, Plon Sharon E, Kimmel Marek
Abstract excerpt
Fluctuation analysis is an established and widely used technique of estimating mutation rates in cultured cells. This paper presents a modified median estimator of mutation rates, which is novel because it allows for unequal population sizes N(t) of the parallel cultures, and helps to detect and reduce the estimation variability. Simulation results show a good accuracy and robustness of the modified median...
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