Accounting for plating efficiency when estimating spontaneous mutation rates.

doi:10.1016/0165-1161(93)90146-q

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Article

Accounting for plating efficiency when estimating spontaneous mutation rates.

Mutation research - 1 Oct 1993

Jones M E

Abstract excerpt

When the spontaneous mutation rate mu in mammalian cell cultures is estimated using Luria-Delbrück fluctuation analysis, many factors contribute to the unreliability of the estimate. Some of these have been documented by Featherstone et al. (1987) and by Kendal and Frost (1988). In particular, th...

Topics

Animals
Cell Division
Cells, Cultured
Mammals
Mathematics
Mutation

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