Article
Very frequent p53 mutations in metastatic prostate carcinoma and in matched primary tumors.
Cancer - 15 Dec 1998
Meyers F J, Gumerlock P H, Chi S G, Borchers H, Deitch A D, deVere White R W
Abstract excerpt
BACKGROUND: The frequency of mutant p53 in bone marrow metastases of patients with carcinoma of the prostate (CaP) and in matched sets of metastatic and primary lesions from the same patients was investigated. The data were examined in relation to prior treatment with androgen ablation (AA) therapy and were compared with the frequency of mutant p53 reported for primary CaP. METHODS: Seventeen patients with M1b...
Topics
- Bone Marrow
- Bone Neoplasms
- Genes, p53
- Humans
- Male
- Mutation
- Neoplasm Proteins
- Polymerase Chain Reaction
- Prostatic Neoplasms
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53